D. Randall Armant, Ph.D.

D. Randall Armant, Ph.D.

Co-Director, Women's Reproductive Health Research (WRHR) Scholar Program

darmant@med.wayne.edu

313-577-1748

D. Randall Armant, Ph.D.

Academic Rank

Professor with Tenure, Research Educator (full time)

Courses taught

PSL 7700 - Course Director. Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Stem Cell Biology.

PSL 7690 - Lecturer. Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Principles of Reproductive Biology.

PSL 7996: Arranged Research - Instructor/Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Current Research Topics in the Reproductive Sciences.

PSL 9991, 9992, 9993, 9994:  Thesis/Dissertation Research and Design- Instructor/Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Doctoral Candidate Status I-IV.

PSL 9995: Candidate Maintenance Status - Instructor/Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Doctoral Candidate Dissertation Research and Direction.

Lecturer. Department of Anatomy & Cell Biology:  Human Embryology.

Lecturer. Department of Obstetrics and Gynecology, Residents and Reproductive Endocrinology and Infertility Conferences.

Advisor/Mentor. Departments of Biochemistry, Biology and Anatomy & Cell Biology; Graduate Research, Laboratory Rotations, Doctoral Candidate Status: Thesis/Dissertation Research and Design, and Doctoral Candidate Dissertation Research and Direction:  Candidate Maintenance Status.

 

Research

Our laboratory investigates signaling pathways that regulate cell adhesion, proliferation and aptosis during early mammalian development. Studies of pre- and peri-implantation development using cultured rodent embryos, as well as human trophoblast cell lines and placental explants, are conducted in our laboratory. Studies are being performed to investigate how extracellular matrices, growth factors and oxygen regulate trophoblast survival and differentiation during blastocyst implantation and placentation. Much of our work has centered on intracellular signaling mediated by members of the epidermal growth factor (EGF) signaling system.

We have reported that heparin-binding EGF-like growth factor is drastically reduced in pre-eclampsia, a disorder characterized by increased trophoblast apoptosis and decreased invasion. As key mechanisms regulating the EGF signaling system and trophoblast functions are resolved, they can be examined for possible roles in pregnancy failure or obstetrical disorders.

Publications

  • Jain CV, Kadam L, van Dijk M, Kohan-Ghadr HR, Kilburn BA, Hartman C, Mazzorana V, Visser A, Hertz M, Bolnick AD, Fritz R, Armant DR, Drewlo S. (2016) Fetal genome profiling at five weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal. Science Translational Medicine, 8:363re4, 2016.
  • Bolnick JM, Kohan-Ghadr HR, Fritz R, Bolnick AD, Kilburn BA, Diamond MP, Armant DR, Drewlo S. (2016) Altered biomarkers in trophoblast cells obtained noninvasively prior to clinical manifestation of perinatal disease. Scientific Reports, 6:32382.
  • Jain CV, Jessmon P, Kilburn BA, Jodar M, Sendler E, Krawetz SA, Armant DR. (2016) Regulation of HBEGF by micro-RNA for survival of developing human trophoblast cells. PLoS ONE, 11:e0163913.
  • Bolnick AD, Bolnick JM, Kilburn BA, Stewart T, Oakes J, Rodriguez-Kovacs J, Kohan-Ghadr HR, Dai J, Diamond MP, Hirota Y, Drewlo S, Dey SK, Armant DR. (2016) Reduced MSX1 in human endometrial tissue is linked to infertility. Human Reproduction. 31:2042-2050.
  • Fritz R, Kohan-Ghadr HR, Bolnick JM, Bolnick AD, Kilburn BA, Diamond MP, Drewlo S, Armant DR. (2015) Noninvasive Detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC). Fertility and Sterility. 104:339-346.e4 .
  • Fritz R, Kohan-Ghadr HR, Sacher A, Bolnick AD, Kilburn BA, Bolnick JM, Diamond MP, Drewlo S, Armant DR. (2015) Trophoblast retrieval and isolation from the cervix (TRIC) is unaffected by early gestational age or maternal obesity. Prenatal Diagnosis. 35:1218-1222.
  • Bolnick JM, Kilburn BA, Bolnick AD, Diamond MP, Singh M, Dai J, Armant DR. (2015) Sildenafil stimulates human trophoblast invasion through nitric oxide and guanosine 3',5'-cyclic monophosphate signaling. Fertility and Sterility. 103:1587-1595.
  • Armant DR, Fritz RB, Kilburn BA, Kim YM, Nien JK, Maihle NJ, Romero R, Leach RE. (2015) Reduced Expression of the Epidermal Growth Factor Signaling System in Preeclampsia. Placenta. 36:270-278.
  • Bolnick JM, Kilburn B, Bajpayee S, Reddy N, Jeelani R, Crone B, Simmerman N, Singh M, Diamond MP, Armant DR. (2014) Trophoblast Retrieval and Isolation from the Cervix (TRIC) for Non-Invasive Prenatal Screening at 5-20 Weeks of Gestation. Fertility and Sterility. 102:135-142.e6.
  • Fritz R, Jain C, Armant DR. (2014) Cell signaling in trophoblast uterine communication. International Journal of Developmental Biology. 58:261-271.
  • Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H, Armant DR. (2013) Physiological and molecular determinants of embryo implantation. Molecular Aspects of Medicine. 34:939-980.
  • Chason RJ, Csokmay J, Segars JH, DeCherney AH, Armant DR. (2011) Environmental and epigenetic impact on preimplantation embryo metabolism and development. [Review] Trends in Endocrinology and Metabolism. 22:412-420.
  • Jessmon P, Kilburn BA, Romero R, Leach RE, Armant DR. (2010) Function specific intracellular signaling pathways downstream of heparin binding EGF-like growth factor utilized by human trophoblasts. Biology of Reproduction, 82:921-929.

 

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Other Information

 Peri-Implantation Development Laboratory