Jennifer Condon, Ph.D.

Jennifer Condon, Ph.D.

Director, Reproductive Physiology Graduate Program; and Co-Director, Women's Reproductive Health Research (WRHR) Scholar Program

jennifer.condon@wayne.edu

313-577-2152

Jennifer Condon, Ph.D.

Academic Rank

Associate Professor with Tenure, Research Educator (full time)

Courses taught

PSL 7690:  Oogenesis I; Oogenesis II; Parturition and the Onset of Preterm Labor - Instructor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Principles of Reproductive Biology. Wayne State University. 2014 to Present

Advisor/Mentor.  Department of Physiology Masters and PhD Program: Doctoral Candidate Status; Thesis/Dissertation Research and Design; and Doctoral Candidate Dissertation Research and Direction: Candidate Maintenance Status. Department of Obstetrics and Gynecology, PGY-4 Resident Research for abstract presented at annual Resident/Fellow Research Day. Wayne State University. 2014 to Present
 
Course or Curriculum Development: Molecular reproductive biology elective for 2nd year graduate student participants of the Development Biology Program, entitled ‘Reproductive Development from Model Organisms to Humans’. University of Pittsburgh 2012-2014
 
Advisor/Mentor. Department of Physiology, Obstetrics and Gynecology and School of Public Health. Masters and PhD Program: Doctoral Candidate Status; Thesis/Dissertation Research and Design; and Doctoral Candidate Dissertation Research and Direction: Candidate Maintenance Status . University of Pittsburgh. 2007-2014
 

 

Professional Experience

 

Wayne State University Professional Experience
Elected Member of the Wayne State University Academic Senate Faculty Hearing Panel

Director of The Reproductive Sciences Graduate Program

Co-Research Director of the Women’s Reproductive Health Research fellowship (WRHR)

Faculty Selection Committee member and candidate interviewer for Chair of Obstetrics and Gynecology.

Scientific Presentation for Combined C.S. Mott Center External Advisory and Internal Advisory Committee Meeting

Promotion and Tenure Committee, Department of Obstetrics and Gynecology

Postdoc and Graduate Student Works in Progress Coordinator Department of Obstetrics and Gynecology, C.S. Mott Center

Shared Equipment Committee C.S. Mott Center, Department of Obstetrics and Gynecology, C.S. Mott Center

Poster Judge for the Wayne State Graduate Student Research Day

Member of the Faculty Recruitment Committee for joint faculty positions with Physiology and Obstetrics and Gynecology

Society Associated Professional Experience
Chair of the Women in Endocrinology Mentoring Committee.

Abstract reviewer and poster discussant and judge for the annual Endocrine Society meeting.

Abstract reviewer and poster discussant and judge for the annual meeting of the Society for Reproductive Investigation,

Chair of the “Basic Parturition IV Hormones, Cytokines & Inflammation/Infection session at the Society for Gynecologic Investigation

Chair of the Female Reproductive Physiology session at the Endocrine Society meeting.


Scholarly Professional Experience
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD/NIH) Pregnancy and Neonatology Study Section Reviewer

Society for Reproductive Investigation Early Career Award Grant Reviewer

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD/NIH) Reviewer for RFA-HD-14-013 entitled: "Obstetric-Fetal Pharmacology Research Centers (OPRC)(U54).”
NICHD/NIH Reviewer for ZRG1 EMNR A (50) Review Panel “Developing Paradigm-Shifting Innovations for in vivo Human Placental Assessment in Response to Environmental Influences (U01).”

NICHD/NIH Reviewer for the Special Emphasis Panel/Scientific Review Group 2016/01 ZRG1 EMNR-A (02) for a set of applications from study section members focused on clinical obstetrics, placental development or pregnancy physiology.

Full Member, NICHD Obstetrics and Maternal-Fetal Biology Study Section (P01, R01, K99, K08, R03, R21, u54).

Board of Medical Research Council (MRC) Reviewer, Population and Systems Medicine, United Kingdom (ad hoc).

Service for Peer-Reviewed Journals
Serve on the editorial board of International Scholarly Research Network Molecular Biology Journal and Gynecology.

Reviewer for the research journals, Science, PNAS, JCI, Biology of Reproduction, Endocrinology, Molecular Endocrinology, Journal of Clinical Endocrinology and Metabolism, Human Reproduction and PLOS one (ad-hoc).
 

Research

The Condon laboratory focuses on defining the molecular mechanisms that regulate gestational length in order to understand the processes the lead to the onset of term and preterm birth. The success of a pregnancy is in part dependent upon the capacity of the pregnant uterine myocyte to maintain a quiescence phenotype despite being exposed to potential uterotonic, intrinsic and extrinsic stimuli across gestation. For an appropriate gestational length to be achieved the pregnant uterine myocyte must detect, tolerate and adapt to pregnancy-associated uterotonic provocations. The Condon lab examines the capacity of the uterine myocyte endoplasmic reticulum stress response to detect potential uterotonic events and generate a tocolytic signaling cascade to accommodate quiescence during these translational episodes. Our preliminary data suggests that the uterine myocyte endoplasmic reticulum stress response and its related unfolded protein response regulate uterine contractile potential during pregnancy in a caspase 3, dependent manner.

 

Publications

1. Ramnarayanan S*, Kyathanahalli C*, Ingles J*, York-Park M, Jeyasuria P, Condon JC. The Unfolded Protein Response Regulates Uterine Myocyte Anti-Oxidant Responsiveness During Pregnancy. Biol Reprod. 2016 Dec; 95(6):120. Epub 2016 Oct 12. PMID: 27733380. Impact Factor 3.945

2. Menon R, Bonney EA, Condon JC, Mesiano S, Taylor RN. Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition. Hum Reprod Update. 2016 Sept; 22(5):535-60. doi: 10.1093/humupd/dmw022. Epub 2016 Jun 30. PMID: 27363410. Impact Factor 11.194

3. Kyathanahalli C*, Organ K*, Moreci RS*, Anamthathmakula P,* Hassan SS, Caritis SN, Jeyasuria P, Condon JC. Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci USA. 2015 Nov 10; 112(45):14090-5 PMID: 26504199. Impact Factor 9.674

4. Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition J Clin Invest. 2015 Jul 1; 125(7):2808-24. PMID: 26098214. Impact Factor 13.26

5. Kyathanahalli C*, Marks J*, Nye K*, Lao B*, Albrecht ED, Aberdeen GW, Nathanielsz PW, Jeyasuria P, Condon JC. Cross-Species Withdrawal of MCL1 Facilitates Postpartum Uterine Involution in Both the Mouse and Baboon. Endocrinology. 2013 Dec; 154(12):4873-84. PMID: 24140717. Impact Factor 4.64

6. Suresh A*, Subedi K*, Kyathanahalli C*, Jeyasuria P, Condon JC. Uterine endoplasmic reticulum stress and its unfolded protein response may regulate caspase 3 activation in the pregnant mouse uterus. PLoS One. 2013 Sep 13; 8(9):e75152. PMID: 24058658. Impact Factor 3.53


7. Williams KC, Renthal NE, Condon JC, Gerard RD, Mendelson CR. miR-200a serves a key role in the decline of progesterone receptor function leading to pre-term and term labor. Proc Natl Acad Sci USA. 2012 May 8; 109(19):7529-34. PMID: 22529366. Impact Factor 9.674

8. Stephenson-Famy A*, Marks J*, Suresh A*, Caritis SN, Simhan H, Jeyasuria P, Condon JC. Antiapoptotic Signaling via MCL1 Confers Resistance to Caspase-3-Mediated Apoptotic Cell Death in the Pregnant Human Uterine Myocyte. Mol Endocrin. 2012 Feb; 26(2):320-30. PMID: 22194343. Impact Factor 4.746

9. Jeyasuria P, Subedi K*, Suresh A*, Condon J. Elevated Levels of Uterine Anti-Apoptotic Signaling Activates NF-kappa B and Confers Resistance to Apoptotic Cell Death During Late Gestation in the Pregnant Mouse. Biology of Reproduction. 2011; Biol Reprod 85:417-424. Impact Factor 4.009

10. Jeyasuria P, Wetzel J*, Bradley M*, Condon J. Progesterone regulated caspase-3 action may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins. Biology of Reproduction. 2009; 80(5):928-34. PMID: 19144964. Impact Factor 3.87

11. Condon J, Hardy DB, Kovaric K, Mendelson CR. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappa B may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol. 2006 Apr; 20(4):764-75. PMID: 16339279. Impact Factor 4.967

12. Mendelson CR, Condon JC. New insights into the molecular endocrinology of parturition. The Journal of Steroid Biochemistry and Molecular Biology. 2005; 93(2-5):113-9. PMID: 15860253. Impact Factor 2.825
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