Reproductive Sciences Retreat and MARTS 2017 Abstracts

Download all Abstracts

2-Cell Embryos are More Sensitive than Blastocysts to AMPK-Dependent Suppression of Anabolism and Potency/Stemness by Commonly Used Fertility Drugs, a Diet Supplement and Stress

A Bolnick1,8, M Abdulhasan1, B Kilburn1, E Secor2, Y Xie3, M Howard4, A Shamir5, J Dai1, E Puscheck1,6, and D Rappolee1,7 
 1CS Mott Center, Ob/Gyn Dept, REI, WSU, Detroit, MI;  2Hartford Hospital and University of Connecticut, Department of Medicine, Hartford. CT:  3Current address: Fertility and Surgical Associates of California, Thousand Oaks, CA;  4EmbryoTech Labs, 140 Hale St Haverhill, MA;   5University of Utah, 201 Presidents Circle, Salt Lake City, UT;  6WSU, IVF clinic 26400 W 12 Mile Rd, Southfield, MI  7Program for Repro Sci, Physiology Dept, WSU, Detroit, MI;   8Corresponding author A Bolnick: abolnickmd@yahoo.com

A Novel Computational and Experimental Approach for Allele-Specific Expression Analysis in High-Throughput Reporter Assays

C. Kalita1, C. Brown3, X. Wen4, R Pique-Regi1,2, F. Luca1,2  
1Center for Molecular Medicine and Genetics, Wayne State University; 2Department of Obstetrics and Gynecology, Wayne State University; 3Department of Genetics, University of Pennsylvania; 4Department of Biostatistics, University of Michigan, Ann Arbor, MI

A Novel Method to Calculate the Mitochondrial DNA/Nuclear DNA Ratio in Human Blastocysts as a Biomarker for Human Embryo Implantation Potential

Svetlana Madjunkova MD, PhD1, Ran Antes PhD1, Rina Abramov MSc1, Ely Fish1, Adina Silver1, Jonah Librach1, Valeriy Kuznyetsov PhD1,  and Clifford Librach MD, PhD1,2,3,4  
1Department for preimplantation genetics, CReATe Fertility Center, Toronto, Canada; 2Department of Obstetrics and Gynecology and 3Department of Physiology, University of Toronto, Toronto, Canada; 4Department of Gynecology, Women’s College Hospital, Toronto, Canada

Abciximab Manifests Striking Anti-Tumor Effects in Sensitive and Chemoresistant Ovarian Cancer Cells

Ghassan M. Saed PhD, Nicole M. Fletcher PhD, Ira Memaj BS
Wayne State University School, Department of Obstetrics and Gynecology, Detroit, MI

An Increase in Sperm DNA Damage after Density Gradient Centrifugation can be Predicted by the Level of Residual Sperm Histones

Andrew Lee1, Bill Yee1,3,Natalia Yasovich1, Sahib Shahani1, Sergey Moskovtsev1,2,Clifford L. Librach1,2,3,4,5  
1Create Fertility Centre, Toronto, ON, Canada; 2Department of Obstetrics and Gynæcology, 3Department of Physiology, 4Institute of Medical Sciences, University of Toronto, ON, Canada; 5Department of Gynæcology, Women’s College Hospital, Toronto, ON, Canada

Application of the haloFISH Assay to Distinguish Chromosomal (Chr) and Extrachromosomal (EC) Telomeric DNA Populations in the Human Sperm Genom

Pamela Kurjanowicz1,2, M. Komosa3, Uri Tabori3, Sergey Moskovtsev2,4,and Clifford Librach1,2,4,5  
1Department of Physiology, University of Toronto; 2Create Fertility Centre; 3Hospital for Sick Children; 4Department of Obstetrics and Gynecology, University of Toronto; 5Department of Gynecology, Women’s College Hospital, Toronto, Ontario

Circulating Maternal GRP78 Levels Predict Timing of the Onset of Labor

Chandrashekara N Kyathanahalli, PhD1,3,Roberto Romero MD1,2,3,4, Sonia Hassan MD1,2,3,4,Jeyasuria Pancharatnam, PhD1,2,3 and Jennifer C Condon, PhD1,2,3 
 1Departments of Obstetrics and Gynecology 2Physiology, Wayne State University School of Medicine; 3Perinatal Research Initiative; 4Perinatology Research Branch, NICHD, Detroit, Michigan,48201

CoQ10 Increases ATP and Oct4 While AMPK Activity and Oocyte Death Decrease During IVM

Abdulhasan1, MK, Li, Q1, Y, Dai1, J, Abu-Soud1, H, Puscheck1, EE, and D.A. Rappolee1,2
 1OB/GYN, Wayne State University, Detroit, MI;  2Department of Physiology, Wayne State University, Detroit, MI

Decidual VEGF can Recruit Macrophages and Induce M2 Polarization, which may Contribute to the Shift in Macrophage Polarity Seen in Preeclampsia

Karen Wheeler1, Manoj Jena1,Bhola Pradhan1, Neha Nayak1, Subhendu Das1,Sabita Dhal1, David Wheeler2, Kang Chen1,Nihar Nayak1  
1Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA; 2Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA

Disruptions in Gene Expression Following Long-Term In Vitro Exposure of Rhesus Macaque Trophoblast Stem Cells to Biologically Relevant Levels of Endocrine Disruptors

Uros Midic1, Benjamin Goheen1,Kailey A Vincent1, Catherine VandeVoort2, and Keith E. Latham1  
1Michigan State University, Department of Animal Science; 2University of California, Davis, California National Primate Research Center

Effects of Palmitic Acid on Development and ER Stress Pathway Transcripts During Mouse Preimplantation Developmen

Maisoon Yousif1, Michele Calder1,2, Dean Betts1,2,3 and Andrew Watson1,2,3
1Departments of Physiology & Pharmacology and 2Obstetrics & Gynaecology Schulich School of Medicine & Dentistry, Western University Canada, London ON;  3Children’s Health Research Institute CHRI, Lawson Health Research Institute, London ON

Endotoxin Effects on the 1st Trimester Human Placenta Can Be Rescued by Rosiglitazone

Leena Kadam1, Dora Baczyk2, Brian Kilburn1, Hamid Reza Kohan-Ghadr1, John Kingdom2, Sascha Drewlo3
1Dept of Obs & Gyn, School of Medicine, Wayne State University, Detroit, Michigan, US;  2The Research Centre for Women's and Infant's Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada;  3Associate Professor, Obstetrics, Gynecology and Reproductive Biology, College Of Human Medicine, Michigan State University

Evaluation of Oxidative Stress (sORP) by MiOXSYS™: a Potential Novel Diagnostic Test for Male Fertility

Bill Yee1,2, Andrew Lee1,Annie Qu1, Sergey Moskovtsev1,3, and Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre, Toronto, ON, Canada; 2Department of Physiology, University of Toronto, Toronto, ON, Canada; 3Department of Obstetrics and Gynæcology, University of Toronto, Toronto, ON, Canada; 4Department of Gynecology, Women’s College Hospital, Toronto, ON, Canada; and 5Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada

Exosomes Derived from Human Umbilical Cord Perivascular Cells Protect Sensory Neurons from Cisplatin-Induced Inhibition of Axon Growt

Emaan Chaudry, Nechama Lipton, FyyazSiddiqui, Lianet Lopez, Andree Gauthier-Fisher, Denis Gallagher and Clifford Librach  
CReATe Fertility Centre

Expression of E3 Ubiquitin Ligase RNF216 in the Mouse Testis

Ashley Melnick1,2, Jiali Liu1,2, Yuen Gao1,2, Alicia Predom1,2, and Chen Chen1,2,3  
1Department of Animal Science, and 2Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI48824, USA;  3Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI 49503, USA

Extracellular Vesicles Derived from Human Umbilical Cord Perivascular Cells (HUCPVCs): A Potential Non-Cell Source for Regenerative Therapy

Lianet Lopez1,  Ansar Khan1,Nechama Lipton, Paula Mackie1, Kathryn Lye1, Farwah Iqbal1,2, Peter Szaraz1,2, Shlomit Kenigsberg1, Denis Gallagher1, Andrée Gauthier-Fisher1, and Clifford L. Librach1,2,3,4,5  
1CReATe Fertility Centre;  2Department of Obstetrics and Gynaecology, 3Department of Physiology, 4Institute of Medical Sciences, University of Toronto; 5Department of Gynecology, Women’s College Hospital, Toronto, Ontario

Extravillous Trophoblast Cell Galectin 13 and Endoglin are Differentially Expressed in Ongoing Pregnancies that Develop Preeclampsia/Fetal Growth Restriction: A Case-Control Study

Steven J. Korzeniewski PhD1,Sascha Drewlo PhD2 and D. Randal Armant PhD1,3  
1Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, USA; 3Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA

Fine Mapping of Chromosomal Aberrations and Mosaicism in Embryos Derived from Donor Oocytes

Svetlana Madjunkova¹, Ran Antes¹, RinaAbramov¹, Valeriy Kuznyetsov¹, Clifford Librach1,2,3,4,5  
¹CReATe Fertility Centre, Toronto, Canada; ²Department of Obstetrics and Gynecology, ³Institute of Medical Sciences and 4Department of Physiology, University of Toronto, Toronto, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada

First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCS) Expanded with CGMP Compliant Human Platelet Lysate Have Superior Regenerative Effect after Myocardial Infarction Compared to Older Sources of MSCS

Alexander Johnston1*, Alexandra Lucato1*, Poonam Mander1, Farwah Iqbal1,3, Ren-Ke Li3, Peter Szaraz1,3*, and Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre; 2Department of Obstetrics and Gynæcology, University of Toronto, Toronto, Canada; 3Institute of Medical Sciences and 4Department of Physiology, University ofToronto, Toronto, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada;   *equal author contribution

First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCS) can Modulate Activated Human Peripheral Lymphocyte Cytokine Secretion

Poonam Mander1, Farwah Iqbal1,2, Nadav Gasner1, Peter Szaraz1,3 and Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre, Toronto, Canada; 2Institute of Medical Sciences, Toronto, Canada; 3Department of Physiology, University of Toronto, Toronto, Canada; 4Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada

First Trimester Umbilical-Derived Umbilical Cord Perivascular Cells (FTM HUCPVC) in Combination with Endothelial Progenitor Cells (EPC) Induce Significantly Improved Angiogenic Response Compared to Single Cell-Type Treatments

Farwah Iqbal, BSc1,2,Brandon Wyse, MSc2, Mugundhine, Sanagaralingam MSc2, Andree Gauthier-Fisher, PhD2, Ren-Ke Li, MD, PhD3, Peter Szaraz, MSc, PhD1,2, Clifford Librach, MD, PhD1,2  
1University of Toronto, Canada; 2Create Program Inc., Toronto, Canada; 3University Health Network, Toronto, Canada

Functional Genomic Analysis of Preeclampsia

Allison Richards1, Cynthia Kalita1, Adnan Alazizi1, Offer Erez2, Roberto Romero1,2,3, Roger Pique-Regi1,3, Francesca Luca1,3  
1Center for Molecular Medicine and Genetics, Wayne State University;2NIH, Perinatology Research Branch; 3Department of Obstetrics and Gynecology, Wayne State University

Genetics and Epigenetics of 5-Hydroxytryptamine Receptor 7 (HTR7) in the Stress and Immune Responses.

Grace Swanson1, Karl Thompson1, Forough Saadatm and2, Georgia Dunston1,4, Clarence Lee3, Muneer Abbas1,4 
1Department of Microbiology, Howard University Graduate School; 2Department of Pediatrics and Child Health, Howard University College of Medicine; 3Department of Biology, Howard University; 4National Human Genome Center, Howard University

Gestational Bisphenol A (BPA) Exposure Induces Inflammatory and Lipotoxic Changes in the Adult Female Sheep Metabolic Tissues

Victoria Andriessen, Muraly Puttabyatappa, Vasantha Padmanabhan  
Department of Pediatrics, University of Michigan, Ann Arbor, MI, 48109

Gestational Exposure to Bisphenol A Induces Oxidative Stress in the Metabolic Tissues of the Female Sheep Offspring

Micaela Stevenson1, Muraly Puttabyatappa1, Subramaniam Pennathur2, Vasantha Padmanabhan1  
1Department of Pediatrics, University of Michigan, Ann Arbor, MI48109; 2Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109

Glucose Deprivation Significantly Increases Pro-Angiogenic Paracrine Activity of First Trimester (FTM) but Not Term Human Umbilical Cord Perivascular Cells (HUCPVCs)

Peter Szaraz1,2, Poonam Mander1, Farwah Iqbal1,3, Nadav Gasner1, and Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre; 2Department of Physiology, University of Toronto; 3Institute of Medical Sciences, Toronto, Canada; 4Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada

High Resolution Analysis of the Mouse Testis Using Single-Cell RNA Sequencing

Qianyi Ma1,3, Christopher D. Green1,3, Jun Z. Li1,2*, and Sue Hammoud1*  
1Department of Human Genetics, University of Michigan, Ann Arbor; 2Department of Computational Medicine and Bioinformatics 3Co-first authors  *Co-corresponding authors

High Throughput Screen (HTS) using viable fluorescent ESC Reporters of Stressed-Forced Differentiation of the First Lineage

E.D. Louden1,2, Q. Li1, Mohammed Abdulhasan1,3, E. E. Puscheck1, J Zhou4, Y. Yang 1,5, S. Drewlo1,6, K. Chen4, and D. Rappolee 1,5  
 1Ob/Gyn department, Wayne State University School of Medicine, Detroit, MI; 2Current address; Regent’s University, Augusta, GA;  3ReproStress Inc, GP Farms, MI;  4Immunology and Microbiology department, Wayne State University School of Medicine, Detroit, MI;  5Reproductive sciences program in Physiology and Ob/Gyn departments, Detroit, MI;  6Current address; Van Andel Institute, Grand Rapids, MI 

Hormonal Regulation of Amygdalar Corticotropin-Releasing Hormone in the Peripartum Period

Sandra Zoubovsky1, Jessie Scheimann1, Lisa Muglia1, Jay Schulkin2, Louis J. Muglia1  
1Cincinnati Children's Hospital Medical Center; 2Georgetown University

Human Villous Trophoblast Mitochondrial Function in Response to a Maternal High Fat Diet

Zachary JW Easton1,2, Christina M Godin Vanderboor1, and Timothy RH Regnault1,2,3,4,5
1Department of Physiology and Pharmacology;  2Collaborative Graduate Program in Developmental Biology;  3Department of Obstetrics and Gynaecology, University of Western Ontario,  4Children’s Health Research Institute;  5Lawson Research Institute, London, ON, Canada

Impact of Long-Term Pessary use on the Quality of Life of Patients and the Anatomical Dimension of Pelvic Organ Prolapse

Chen Dong Yao1, Yves Bureau2, and Queena Chou3  
1Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada,  2Lawson Health Research Institute, 3Schulich School of Medicine and Dentistry, Departments of Obstetrics and Gynaecology, The University of Western Ontario, London, Ontario, Canada

Interleukin-33-Induced Expression of PIBF1 by Decidual B Cells Protects Against Preterm Labor

Bihui Huang1, Michael D. Pawlitz1,3, Azure N. Faucette1, Bo Pei1, Joshua W Goyert1 Jordan Zheng Zhou1,  Fayi Yao1, Jason Lin1, Japnam Jassal1, Robert S. Dewar III1, Lisa Polin2, and Kang Chen1,2,3  
1Department of Obstetrics and Gynecology, Wayne State University; 2Department of Oncology, Wayne State University; 3Department of Microbiology, Immunology, and Biochemistry, Wayne State University

Intra-Ovarian Injection of First Trimester Human Umbilical Cord Perivascular Cells (FTM-HUCPVCs) Protects Against Chemotherapy-Induced Ovarian Damage in a Rat Model

Meredith Garcia1*, Khaled Zohni1,2*, Lianet Lopez1*, Peter Szaraz1, Karen Glass1,2,5, Andrée Gauthier Fisher1, and Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre; 2Department of Obstetrics and Gynæcology, University of Toronto, Toronto, Canada; 3Institute of Medical Sciences and 4Department of Physiology, University of Toronto, Toronto, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada   *indicates equal author contribution

Irisin Protects Human Placenta from Hypoxia/Re-Oxygenation Induced Oxidative Stress and Apoptosis by Regulating PI3K/Akt Signaling Pathway

Hamid Reza Kohan-Ghadr, PhD1, Leena Kadam, MSc2, Brian Kilburn, BSc1 and Sascha Drewlo, PhD1  
1Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States, 48201;  2Physiology & Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States, 48201

Loss of p66shc Accelerates the Cell Cycle and the Onset of GATA4 Expression in Mouse Blastocysts

Nicole A. Edwards, Andrew J. Watson, Dean H. Betts   
Collaborative Graduate Program in Developmental Biology, Departments of Physiology and Pharmacology, Obstetrics & Gynaecology, The University of Western Ontario, The Children’s Health Research Institute, London, ON, Canada

Modulation of Murine Immune System During Pregnancy by Placental Exosomes

SL Nguyen1,2, JW Greenberg3,BW Collaer4, & MG Petroff3,5   
1Cell and Molecular Biology, Michigan State University, East Lansing, MI, USA; 2Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; 3Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA; 4Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA; 5Pathobiology Diagnostic Investigation, Michigan State University, East Lansing, MI, USA

Optimizing a Procedure for the Isolation and Purification of Human Granulosa Cells for Biobanking Purposes

Sydney Flatt1, Sahar Jahangiri1, Mugundhine Sangaralingham1, Brandon A. Wyse1,and Clifford L. Librach1,2,3,4,5  
1CReATe Fertility Centre, Toronto, Canada; 2Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada; 3Institute of Medical Sciences and 4Department of Physiology, University of Toronto, Toronto, ON, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, ON, Canada

PLK1 Regulates EIF4EBP1 Phosphorylation on Mouse Oocyte Spindles

Ashley L. Severance, Keith E. Latham
Michigan State University, East Lansing, MI, Reproductive and Developmental Sciences Program, Genetics Program

PNLDC1 is Essential for piRNA 3' End Trimming and Transposon Silencing During Spermatogenesis in Mice

Deqiang Ding, Chen Chen 
Department of Animal Science, Michigan State University, East Lansing, Michigan

Physiological di-Butyl Phthalate Exposure Alters Human Sperm RNA

Molly S. Estill1, Russ Hauser3, Alan C. Moss4, Stephen A. Krawetz1,2   
1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA;  2Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA;  3Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, and Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA;  4Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA

Postnatal Catch-Up Growth in Low Protein IUGR Offspring Leads to Increased Expression of Hepatic microRNA-140: Mechanism of Premature Senescence?

Shelby L. Oke1,5, Daniel B. Hardy1,2,3,4,5  
Departments of 1Physiology and Pharmacology, 2Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry;  3Children’s Health Research Institute;  4Lawson Health Research Institute;  5Western University, London, ON, Canada

Preconditioning by Endogenous Gestational Stresses Capacitates Uterine Quiescence During Pregnancy

Judith Ingles1, Arren Simpson4, Jeyasuria Pancharatnam1,2,3, and Jennifer Condon 1,2,3  
Departments of 1Physiology, 2Obstetrics and Gynecology, and the 3Perinatal Research Initiative, Wayne State University School of Medicine, Detroit, Michigan 48201;  4Department of Biology, University of Detroit Mercy, Detroit, MI, 48221

Scyllo Inositol Does Not Affect Umbilical Cord Perivascular Cell Biology In Vitro: Potential Combination Therapy for Alzheimer's Disease

Luqmaan Moolla1, Denis Gallagher1, Fyyaz Siddiqui1, Lynsie Thomason2, Andrée Gauthier Fisher1, Bojana Stefanovic2, JoAnne McLaurin2 and Clifford Librach1,3,4,5,6,7  
1CReATe Fertility Centre; 2Sunnybrook Research Institute, Department of Biological Sciences; 3Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada; 4Institute of Medical Sciences and 5Department of Physiology, University of Toronto, Toronto, ON, Canada; 6Department of Gynecology, Women’s College Hospital, Toronto, ON, Canada; 7Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Small RNAs in Spent Human Embryo Culture Media as Biomarkers of Embryo Implantation Potential

Stewart Russell1, Karen Menezes1, Hanna Balakier1, Clifford Librach1,2,3,4,5  
1CReATe Fertility Centre; 2Department of Obstetrics and Gynæcology, University of Toronto, Toronto, ON, Canada; 3Institute of Medical Sciences; 4Department of Physiology, University of Toronto, Toronto, ON, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, ON, Canada

Sperm RNA Elements and Boar Sperm Quality

Marta Gòdia1, Molly Estill2, Anna Castelló1, Juan-Enrique Rodríguez-Gil3, Stephen A. Krawetz2, Armand Sánchez1, Alex Clop1     1Center for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Bellaterra (Barcelona), Spain;  2Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA;  3Unit of Animal Reproduction, Department of Animal Medicine and Surgery, Universitat Autònoma de Barcelona, Bellaterra (Barcelona), Spain

Steroid Hormone Regulation of PIK3IP Expression in the Murine Uterus

Hanna E. Teasley, Hye Jin Chang, Tae Hoon Kim, and Jae-Wook Jeong 
Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, MI 49503

The Estrogen Receptor Delta 7 Isoform Regulates Myometrial Contractility in Gestation

Prashanth Anamthathmakula, PhD2,3,Jennifer C Condon, PhD1,2,3 and Pancharatnam Jeyasuria, PhD1,2,3
Departments of 1Physiology, 2Obstetrics and Gynecology; and the 3Perinatal Research Initiative, Wayne State University School of Medicine, Detroit, Michigan, 48201

The Impact Single (hCG) or Dual (hCG + GNRH) Triggers have on the Cumulus Cell Transcriptome in Patients with a Normal Ovarian Reserve

Brandon A. Wyse1, Noga Fuchs Weizman1, Itai Gat1, Hanna Balakier1, Shlomit Kenigsberg1, Mugundhine Sangaralingam1, Stewart Russell1,Julieta Caballero1, Clifford Librach1,2,3,4,5 
 1CReATe Fertility Centre, Toronto, Canada; 2Department of Obstetrics and Gynæcology; 3Department of Physiology, 4Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; 5Department of Gynecology, Women’s College Hospital, Toronto, ON, Canada

The Molecular Interplay Between ARID1A and PGR is Crucial in Maintaining Pregnancy

Tae Hoon Kim1, Jung-Yoon Yoo1, Hye Jin Chang1, Zhong Wang2, Steven L. Young3, Bruce A. Lessey4 and Jae-Wook Jeong1,5  
1Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, MI 49503; 2Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114; 3Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, 27599; 4Department of Obstetrics and Gynecology, University Medical Group, Greenville Health System, Greenville, SC, 29605; and 5Department of Women’s Health, Spectrum Health System, Grand Rapids, MI, 49341

Transcriptome Analyses of Rhesus Monkey Oocytes that Failed to Mature Reveal Key Molecular Pathways that Deviate from Normal Meiotic Maturation

Meghan L. Ruebel1, Peter Schall1, Uros Midic1, Kailey A. Vincent1, Catherine A. VandeVoort2, and Keith E. Latham1  
1Department of Animal Science and Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan; 2California National Primate Research Center and Department of Obstetrics and Gynecology, University of California, Davis, California

Transcriptomic Analysis of Trophoblast Cells Obtained Non-Invasively in the First Trimester of Ongoing Pregnancies to Investigate Severe Uteroplacental Insufficiency

Chandni V. Jain1,2, Hamid Reza Kohan-Ghadr2, Brian A. Kilburn2, Rani Fritz2,Alan D. Bolnick2, Stephen A. Krawetz2,3, Sascha Drewlo2,and D. Randall Armant2,4,5  
Departments of 1Physiology, 2Obstetrics and Gynecology, 3Centre for Molecular Medicine and Genetics, 4Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

Two-Component System Diversity Across Group B Streptococcus (GBS) Clinical Isolates

Cole McCutcheon1, Dr. Margaret Petroff1,2, and Dr. Shannon Manning1
1Department of Microbiology and Molecular Genetics, Michigan State University East Lansing, MI; 2Department of Department of Pathobiology & Diagnostic Investigation

Use of TEX101 Antibodies to Negatively Select for the Best Quality Mature Sperm: A Potential Novel Methodology to Select Sperm for IVF

Junyan Zhang1, Christina Schiza2, Andrei Drabovich2, Kirk Lo3,4, Keith Jarvi2,4, Eleftherios P. Diamandis2, Andrée Gauthier Fisher1, Sergey I Moskovtsev1,3, Clifford Librach1,3,5  
1CReATe Fertility Centre, Toronto; 2Department of Lab Medicine & Pathobiology, University of Toronto;  3Department of Obstetrics & Gynecology, University of Toronto; 4Murray Koffler Urologic Wellness Centre, Mount Sinai Hospital, Toronto; 5Department of Gynecology, Women’s College Hospital, Toronto, Canada

circuitSNPs: Predicting Effects Of Genetic Regulatory Variants Using Deep Neural Networks

Alexander Shanku, Cindy Kalita, Anthony Findley, Francesca Luca, Roger Pique-Regi 
WSU