Chaur-Dong Hsu

Chaur-Dong Hsu

Chair and Frank P. Iacobell Professor, Department of Obstetrics and Gynecology; Professor, Department of Physiology, Wayne State University School of Medicine; Project Site Manager and Director, Center for Advanced Obstetric Care and Research, Perinatology Research Branch, National Institutes of Health (NIH); Program Director and Principal Investigator, Women's Reproductive Health, National Institutes of Health (NIH); Specialist-in-Chief, OB/GYN, Detroit Medical Center; Chief, OB/GYN, Karmanos Cancer Institute

313-993-4049

Chaur-Dong Hsu

Academic Rank

• Chair and Frank P. Iacobell Professor, Department of Obstetrics and Gynecology
• Professor, Department of Physiology, Wayne State University School of Medicine
• Project Site Manager & Director, Center for Advanced Obstetric Care and Research,
    Perinatology Research Branch, National Institutes of Health (NIH)
• Specialist-in-Chief, OB/GYN, Detroit Medical Center
• Chief, OBGYN, Barbara Ann Karmanos Cancer Institute
• Program Director and Principal Investigator, Women's Reproductive Health Research, NIH

Awards and Honors

  • CREOG, Excellence in Teaching Award
  • Best Faculty Teaching Award
  • Best Doctors in America
  • American TOP OB/GYN
  • Top Doctor in the Nation, New York Times
  • Best Doctor, New York Magazine
  • Top Doctors for Women's Health, New York Times
  • Best Doctor of New York, Castle Connolly
  • Berlex Junior Faculty Award
  • ACOG-Ethicon District IV Award, ACOG
  • President, Women Physician of Westchester, Westchester, New York
  • Board of Directors, North American Society for the Study of Hypertension in Pregnancy
  • Secretary and Treasurer, North American Society for the Study of Hypertension in Pregnancy
  • Editorial Board, Gynecology and Women's Health Research (Editorial Board)
  • International Board, Taiwan Journal of Obstetrics and Gynecology (International Board

Education

  • M.D. Kaohsiung Medical University, Kaohsiung, Taiwan
  • M.P.H. The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland

Post Graduate Training

  • Resident – Department of Obstetrics and Gynecology, Beth Israel Medical Center, New York, New York
  • Postdoctoral Training – Postdoctoral Clinical Fellow and Research Fellow, 
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology,
    The Johns Hopkins University School of Medicine, Baltimore, Maryland

Professional Experience

  • Associate Director in Research of Maternal-Fetal Medicine Fellowship Program in, Yale University
  • Director, Maternal-Fetal Medicine Fellowship Program & Research, Duke University
  • Leon McGoogan Endowed Chair and Professor, University of Nebraska
  • Chair/Director and Professor with Tenure of the Department of Obstetrics and Gynecology, Westchester Medical Center, New York Medical College, New York
  • Professor with Tenure of Obstetrics, Gynecology and Reproductive Medicine, Stony Brook School of Medicine, New York
  • Chair of the Department of Obstetrics and Gynecology, NuHealth System, SUNY Stony Brook School of Medicine, New York

Research

Research Accomplishments

  • Reduction of Cesarean section surgical site infection (Hsu Bundle)
  • The role of the maternal Fas-FasL gene in the Great Obstetrical Syndrome: preeclampsia, fetal growth restriction
  • Biomarkers for preeclampsia (Early- and Late-Onset Preeclampsia)
  • Amniotic fluid biomarkers that signify infection

Research Interests

  • Apoptosis & Fas-FasL Signal Pathway
  • Fas-FasL Gene Polymorphism
  • Surgical Site Infection Bundle (Hsu Bundle)
  • Preterm Labor & Immunology
  • Personalized Obstetrics
  • Biomarkera in Intra-amniotic Infection

Publications

Select Publications

  • Theis KR, Romero R, Motomura K, Galaz J, Winters AD, Pacora P, Miller D, Slutsky R, Florova V, Levenson D, Para R, Varrey A, Kacerovsky M, Hsu CD, Gomez-Lopez N. Microbial Burden and Inflammasome Activation in Amniotic Fluid of Patients With Preterm Prelabor Rupture of Membranes. J Perinat Med, 48 (2), 115-131; 2020 Feb 25. PMID: 31927525 DOI: 10.1515/jpm-2019-0398
  • Helmi H, Siddiqui A, Yan Y, Basij M, Hernandez-Andrade E, Gelovani J, Hsu CD, Hassan SS, Mehrmohammadi M. The Role of Noninvasive Diagnostic Imaging in Monitoring Pregnancy and Detecting Patients at Risk for Preterm Birth: A Review of Quantitative Approaches. J Matern Fetal Neonatal Med, 1-24; 2020 Feb 23. PMID: 32089024 DOI: 10.1080/14767058.2020.1722099
  • Galaz J, Romero R, Slutsky R, Xu Y, Motomura K, Para R, Pacora P, Panaitescu B, Hsu CD, Kacerovsky M, Gomez-Lopez N. Cellular Immune Responses in Amniotic Fluid of Women With Preterm Prelabor Rupture of Membranes. J Perinat Med 2020 Feb 14. PMID: 32083453 DOI: 10.1515/jpm-2019-0395
  •  Para R, Romero R, Gomez-Lopez N, Tarca AL, Panaitescu B, Done B, Hsu R, Pacora P, Hsu CD. Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia. J Matern Fetal Med, 1-14; 2020  Feb 2. PMID:32008387 DOI:10.1080/14767058.2020.1716720.
  • Alhousseini A, Romero R, Behshalom-Tirosh N, Gudicha D, Pacora P, Tirosh D, Yeo L, Thachil J, Hsu, CD, Hassan SS, Offer, E. Nonovert disseminated intravascular coagulation (DIC) in pregnancy: A new scoring system for the identification of patients at risk for obstetrical hemorrhage requiring blood product transfusion. J Matern Fetal Neonatal Med, 1-16; 2020 Feb 3. PMID:31931643 DOI: 10.1080/14767058.2020.1716330.
  • Tarca AL, Romero R, Pique-Regi R, Pacora P, Done B, Kacerovsky M, Bhatti G, Jaiman S, Hassan SS, Hsu CD, Gomez-Lopez N. Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy. BMC Med Genomics, 13 (1), 252020 Feb 12. PMID:32050959 PMCID:PMC7017452 DOI:10.1186/s12920-020-0690-5.
  • Theis K, Romero R, Motomura K, Galaz J, Winters A, Pacora P, Miller D, Slutsky R, Florova V, Levenson D, Para R, Varrey A, Kacerovsky M, Hsu CD, Gomez-Lopez N. Microbial burden and inflammation activation in amniotic fluid of patients with preterm prelabor rupture of membranes. J Perinatol Med 2020 Jan 13. pii: /j/jpme.ahead-of-print/jpm-2019-0398/jpm-2019-0398.xml. doi: 10.1515/jpm-2019-0398. [Epub ahead of print]. PMID: 31927525
  • Galaz J, Romero R, Xu Y, Miller D, Slutsky R, Gingell L, Hsu CD, Gomez-Lopez N. Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis. Inflammation Research 2020 Jan 7. Doi: 10.1007/s00011-019-01308-x [Epub ahead of print]. PMID: 31912179
  • Schwenkel G, Romero R, Slutsky R, Motomura K, Hsu CD, Gomez-Lopez N. HSP70: An alarmin that does not induce high rates of preterm birth but does cause adverse neonatal outcomes. J Matern Fetal Neonatal Med 2020 Jan 6:1-9. doi: 10.1080/14767058.2019.1706470. [Epub ahead of print]. PMID: 31906756
  • Tarca AL, Romero R, Erez O, Gudicha DW, Than NG, Benshalom-Tirosh N, Pacora P, Hsu CD, Chaiworapongsa T, Hassan SS, Gomez-Lopez N. Maternal whole blood mRNA signatures identify women as risk of early preeclampsia: a longitudinal study. J Matern Fetal Neonat Medicine 2020 Jan 3:1-12. doi: 10.1080/14767058.2019.1685964. [Epub ahead of print]. PMID: 31900005
  • Galaz J, Romero R, Slutsky R, Xu Y, Motomura K, Para R, Pacora P, Panaitescu B, Hsu CD, Kacerovsky M, Gomez-Lopez N. Cellular immune responses in women with preterm prelabor rupture of membranes. J Perinat Med 2020, December 2019 doi.org/10.1515/jpm-2019-0395.
  • Romero R, Gomez-Lopez N, Winters AD, Jung E, Shaman M, Bieda J, Panaitescu B, Pacora P, Erez O, Greenberg JM, Ahmad MM, Hsu CD, Theis KR. Evidence that intra-amniotic infections are often the result of an ascending invasion – a molecular microbiological study. J Perinatol Med 2019 Nov 26; 47(9):915-31. PMID: 31693497
  • Gomez-Lopez N, Romero R, Leng Y, Slutsky R, Levenson D, Pacora P, Jung E, Panaitescu B, Hsu CD. The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection. J Perinatol Med 2019 Oct 25;47(8):822-40.Sep 7 doi: 10.1515/jpm-2019-0262 [Epub ahead of print] PMID: 31494640..
  • Gomez-Lopez N, Romero R, Xu Y, Miller D, Arenas-Hernandez M, Garcia-Flores V, Panaitescu B, Galaz J, Hsu CD, Berry SM. Fetal T-cell activation in the amniotic cavity during preterm labor: A potential etiology for a subset of idiopathic preterm birth. J Immunol 2019;203:1793-1807. PMID: 31492740.
  • Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zhou C, Gudicha DW, Tarca AL, Para R, Hassan SS, Hsu CD. Gasdermin D: evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection. Am J Reprod Immunol 2019 Aug 28 doi: 10.1111/aji13184. [Epub ahead of print] PMID: 31461796
  • Gomez-Lopez N, Romero R. Galaz J, Xu Y, Panaitescu B, Slutsky R, Motomura K, Gill N, Para R, Pacora P, Jung E, Hsu CD. Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation. Am J Reprod Immunol 2019 Jul 19:e13171.doi: 10.1111/aji.13171 (Epub ahead of print]. PMID: 31323170
  • Winters AD, Romero R, Gervasi MT, Gomez-Lopez N, Tran MR, Garcia-Flores V, Pacora P, Jung E, Hassan SS, Hsu CD, Theis KR. Does the endometrical cavity have a molecular microbial signature? Scientific Reports 2019 Jul 9:9(1):9905. PMID: 31289304
  • Para R, Romero R, Miller D, Panaitescu B, Varrey A, Chaiworapongsa T, Hassan SS, Hsu CD, Gomez-Lopez N. Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2019 Apr 18:1-16. Doi: 10.1080/147670458.2019.1597047 [Epub ahead of print] PMID: 30999788.
  • Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zhou C, Gudicha DW, Tarca AL, Para R, Hassan SS, Hsu CD. Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term. J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Doi: 10.1080/14767058.2019.1610440 [Epub ahead of print] PMID: 31006293.
  • Shafik S, Mallick S, Fogel J, Tetrtokalashvili M, Hsu CD. The utility of systemic inflammatory response syndrome (SIRS) for diagnosing sepsis in the immediate postpartum period. J Infect Public Health 2019 Nov-Dec;12(6):799-802. PMID: 31010644.
  • Arenas-Hernandez M, Romero R, Panaitescu B, Garcia-Flores V, Ahn H, Done B, Hassan SS, Hsu CD, Sanchez-Torres C, Gomez-Lopez N. Effector and activated T cells induce preterm birth that is prevented by treatment with progesterone. J Immunol 2019 May 1;302(9):2585-2608. Doi:10.4049/jimmunol. 1801350. Epub 2019 Mar 27. PMID: 30918041.
  • Pacora P, Romero R, Erez O, Maymon E, Panaitescu B, Kusanovic JP, Tarca AL, Hsu CD, Hassan SS. The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species. J Matern Fetal Neonatal Med 2019 May;32(10):1703-20. ;doi: 10.1080/14767058.2017.1416083. [Epub 2017 Dec 27] PMID:29226760.
  • Gill N, Leng Y, Romero R, Xu Y, Panaitescu B, Miller D, Arif A, Mumuni S, Qureshi F, Hsu CD, Hassan SS, Staff AC, Gomez-Lopez N. The immunophenotype of decidual macrophages in acute atherosis. Am J Reprod Immunol 2019 Apr;81(4):e13098. Doi: 10.1111/aji. 13098. Epub 2019 Mar 4. PMID: 30734977
  • Tarca AL, Romero R, Xu Z, Gomez-Lopez N, Erez O, Hsu CD, Hassan SS, Carey VJ. Targeted expression profiling by RNA-Seq improves detection of cellular dynamics during pregnancy and identified a role for T-cells in term parturition. Scientific Reports 2019 Jan29;9(1):848. PMID: 30696862.
  • Shafik S, Mallick S, Fogel J, Tetrtokalashvili M, Hsu CD. The utility of systemic inflammatory response syndrome (SIRS) for diagnosing sepsis in the immediate postpartum period. J Infect Public Health 2019 Apr 19.pii:S1876-0341(19)30136-4. Doi: 10.1016j.jiph.2019.04.003 [Epub ahead of print]. PMID: 31010644.
  • Hsu, C-D, Cohn, I, Caban, R. Reduction and sustainability of Cesarean section surgical site infection: an evidence-based, innovative, and multidisciplinary quality improvement intervention bundle program. Am J Infect Control. 2016;44(11):1315-20. PMID:27317407


PUBMED PUBLICATIONS:
pubmed.ncbi.nlm.nih.gov/

 

 

 

 

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