Nardhy Gomez-Lopez, Ph.D.

Nardhy Gomez-Lopez, Ph.D.

Assistant Professor

nardhy.gomez-lopez@wayne.edu

313-577-8904

Nardhy Gomez-Lopez, Ph.D.

Academic Rank

Assistant Professor, Research Educator (full time)

Courses taught

PSL 7690:  Immune Mediators that Lead to Term and Preterm Labor Instructor. Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Principles of Reproductive Biology. 

PBL Facilitation.  Wayne State University School of Medicine, Immunology and Microbiology (Y2 Medical Students): . Pathophysiology of Trypanosoma Cruzi. 
 
Instructor.  Wayne State University School of Medicine, Medical Physiology (Medical Students):  Puberty; Pregnancy and Parturition; Pregnancy Complications.
 
Instructor.  Perinatology Research Branch/NIH/NICHD, Immunological Basic Concepts and Journal Club (MFM Fellows and Research Associates):  Preparing presentations of relevant immunological topics and cases.
 
Instructor.  Perinatology Research Branch/NIH/NICHD, Reproductive Science Lecture Series (MFM Fellows):  Reproductive Immunology.
 
PSL 7996:  Arranged Research - Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Current Research Topics in the Reproductive Sciences.
 
PSL 9991, 9992, 9993, 9994: Thesis/Dissertation Research and Design - Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Doctoral Candidate Status I-IV.
 
PSL 9995: Candidate Maintenance Status  - Advisor/Mentor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Doctoral Candidate Dissertation Research and Direction.
 
Advisor/Mentor.  Departments of Molecular Biomedicine and Molecular Biology & Genetics PhD Programs: Graduate Research; Laboratory Rotations; Doctoral Candidate Status: Thesis/Dissertation Research and Design; and Doctoral Candidate Dissertation Research and Direction:  Candidate Maintenance Status. 
 
Advisor/Mentor.  Departments of Immunology and Public Health Master Programs.

Research

Our laboratory investigates immunological pathways and preterm birth in both human and animal models. Our objective is to develop novel diagnostic, therapeutic and preventive strategies to reduce adverse pregnancy outcomes, such as preterm birth. Current work focuses on the role of regulatory and effector T cells and the effect of the paternal fetal antigen during pregnancy and preterm birth. This work is carried out by using animal models (transgenic and knockout mice) and molecular biology techniques such as flow cytometry, microscopy, RT-PCR. These approaches allow the identification of phenotypes and intracellular components, such as DNA, messenger RNA for particular genes, specific surface receptors, intracellular proteins, and transient signaling events in living cells. The combination of these approaches allows the identification of etiological factors of preterm birth and other related pregnancy pathologies in humans, develop novel diagnostic, therapeutic and preventive strategies to reduce adverse pregnancy outcomes.

Publications

1. A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis. Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Leng Y, Than NG, Chaiworapongsa T, Panaitescu B, Dong Z, Tarca AL, Abrahams VM, Yeo L, Hassan SS. Reproductive Sciences, 2017 [Epub ahead of print]
 
2. Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense. Gomez-Lopez N, Romero R, Leng Y, Garcia-Flores V, Xu Y, Miller D, Hassan SS. American Journal of Reproductive Immunology, 2017 [Epub ahead of print]
 
3. Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense. Gomez-Lopez N, Romero R, Xu Y, Miller D, Unkel R, Shaman M, Jacques SM, Panaitescu B, Garcia-Flores V, Hassan SS. Reproductive Sciences, 2016 [Epub ahead of print]
 
4. An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment. Xu Y, Romero R, Miller D, Kadam L, Mial TN, Plazyo O, Garcia-Flores V, Hassan SS, Xu Z, Tarca AL, Drewlo S, Gomez-Lopez N. Journal of Immunology 196(6):2476-91, 2016.
 
5. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, Milovic T, Xu Z, Bhatti G, Mi QS, Drewlo S, Tarca AL, Hassan SS, Gomez-Lopez N. Journal of Immunology 196(3):1044-59, 2016.

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