Awoniyi Awonuga

Awoniyi Awonuga

Professor and Kamran S. Moghissi, MD Endowed Chair, Division of Reproductive Endocrinology and Infertility

aawonuga@med.wayne.edu

248-352-8200

248-356-8255 (fax)

Awoniyi Awonuga

Academic Rank

Professor

Office Address

WSUPG – Southfield Office
26400 W. 12 Mile Road, Suite 140
Southfield, MI 48034

Biography

Dr. Awonuga MD, FRCOG, FACOG is a Professor in the Department of Obstetrics and Gynecology and the Division of Reproductive Endocrinology and Infertility (REI). He is the Kamran S. Moghissi, MD, Endowed Chair in Obstetrics and Gynecology in REI. He received his medical degree from the University of Ibadan Medical School in Nigeria in 1979. He later completed residency in Ob/Gyn at the Lagos University Teaching Hospital, Nigeria and a residency (Ob/Gyn) and fellowship in reproductive endocrinology and infertility (REI) in the United Kingdom. He is an accredited Specialist in Ob/Gyn in the United Kingdom and he is a Fellow of the Royal College of Obstetricians and Gynaecologists. Dr. Awonuga completed residency in Ob/Gyn at Maimonides Medical Center in New York and Fellowship in Reproductive Endocrinology and Infertility at Wayne State University. Upon completing fellowship in REI, he completed scholarly training in the Women’s Reproductive Health Research (WRHR) Career Development Program of NIH/NICHD. Dr. Awonuga is the Director of the Polycystic Ovary Syndrome Center. He is actively involved in medical students’, residents’ and fellows’ education, teaching, and research as attested to by the various accolades he has received from Residents and Fellows over the years. Dr. Awonuga is an active member of several committees within the department including: Promotion and Tenure Committee; Research Opportunities and Growth Committee; Faculty Selective Salary Committee. He is an ad hoc reviewer for 10 international and 6 national journals in Ob/Gyn and he has editorial board membership in several journals. Dr. Awonuga is a motivated, self-inspired and committed academic obstetrician and gynecologist with more than 50 (of over 100 in total) original publications of which he is the first or senior author. Dr. Awonuga is a member of several major professional societies including; American Society for Reproductive Medicine, Royal College of Obstetricians and Gynaecologists and the American College of Obstetricians and Gynecologists.

Specialties

Reproductive Endocrinology and Infertility 

  1. The ASRM Star Award yearly 2017 - 2019
  2. Wayne State University School of Medicine’s College Teaching Award 2016
  3. Kamran S. Moghissi, M.D. Faculty Award, WSU, Dept. of OB/GYN 2013
  4. National Council of Resident Education (CREOG) 2005, 2006, 2012
  5. Biography selected for inclusion: On and off since 2011
               Who’s Who in America by Marquis Who’s Who
               America’s Top Obstetrician and Gynecologists
  6. Excellence in Teaching Award, Depart. of Ob/Gyn, Mount Sinai School of Medicine, NY 2004

 

Medical

University of Ibadan Medical School in Nigeria in 1979

Residency

Lagos University Teaching Hospital, Nigeria and a residency (Ob/Gyn) 1982-1986
United Kingdom 1987-1989
Maimonides Medical Center 2000-2003
 

Fellowships

Reproductive endocrinology and infertility (REI), United Kingdom. 1992-1993
Higher Specialist training, RCOG, United Kingdom 1999-2000
Fellowship in REI at Wayne State University 2007-2010
 

Research Interests

• Critical appraisal and evidence-based medicine
• Polycystic ovary syndrome
• Difficult and challenging infertility cases,
• IVF success
• Oocyte and embryo physiology and embryo implantation
• Intraperitoneal adhesions.
 

Other Information

 Publications: 2019 –To date

  1. Elizabeth E. Puscheck, Ximena Ruden, Aditi Singh, Mohammed Abdulhasan, Douglas M. Ruden, Awoniyi O. Awonuga, Daniel A. Rappolee. Using high throughput screens to predict miscarriages with placental stem cells and long-term stress effects with embryonic stem cells. Birth Defect Research. Using high throughput screens to predict miscarriages with placental stem cells and long-term stress effects with embryonic stem cells. Birth Defects Research. 2022, Aug 18:144(4);
  2. Mohammed Abdulhasan, Ximena Ruden, Yuan You, Sean M. Harris, Douglas M. Ruden, Awoniyi O. Awonuga, Ayesha Alvero, Elizabeth E. Puscheck and Daniel A. Rappolee. Using live imaging and FUCCI ESC to distinguish G1 cell cycle delays, general stressors like PFOA and hyperosmotic sorbitol or G2 cell cycle delay for mutagenic stressors like benzo(a)pyrene. Stem Cells Dev. 2022 Jun;31(11-12):296-310.
  3. Mohammed Abdulhasan , Ximena Ruden, Teya Marben , Sean Harris, Douglas M Ruden, Awoniyi O Awonuga, Elizabeth E Puscheck, Daniel A Rappolee. Using Live Imaging and Fluorescence Ubiquitinated Cell Cycle Indicator Embryonic Stem Cells to Distinguish G1 Cell Cycle Delays for General Stressors like Perfluoro-Octanoic Acid and Hyperosmotic Sorbitol or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a)pyrene. Stem Cells Dev. 2022 Jun;31(11-12):296-310.
  4. Mohammed Abdulhasan, Ximena Ruden, Yuan You, Sean M. Harris, Douglas M. Ruden, Awoniyi O. Awonuga, Ayesha Alvero, Elizabeth E. Puscheck and Daniel A. Rappolee. Using Live Imaging and FUCCI Embryonic Stem Cells to Rank Dev Tox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude. Front. Toxicol., 30 November 2021 https://doi.org/10.3389/ftox.2021.709747
  5. Martins Ayoola-Adeola, Ramya Sethuram, Damla Gonullu, Awoniyi Awonuga. Massive ovarian edema masquerading as an androgen secreting tumor. Accepted, Fertil and Steril Rep. 2021 Sep 30;2(4):468-471.
  6. Awoniyi O. Awonuga, Charalampos Chatzich aralampous, Mili Thakur, Anupama Rambhatla, Farnoosh Qadri, Modupe Awonuga, Ghassan Saed, Michael P. Diamond. Genetic and epidemiological similarities, and differences between postoperative intraperitoneal adhesion development and other benign fibro-proliferative disorders. Accepted for publication. Reprod Sci. 2021 Sep 13. doi: 10.1007/s43032-021-00726-9.
  7. Thakur M, Rambhatla A, Qadri F, Chatzicharalampous C, Awonuga M, Saed G, Diamond MP, Awonuga AO. Is There a Genetic Predisposition to Postoperative Adhesion Development? Reprod Sci. 2021 Aug;28(8):2076-2086.
  8. Damla C. Gonullu, Xiao M. Huang, LeRoy G. Robinson, Christopher A. Walker, Martins Ayoola-Adeola, Rebecca Jameson, Dorothy Yim, Awoniyi Awonuga. Tubal Factor Infertility and its Impact on Reproductive Freedom of African American Women. Am J Obstet Gynecol. 2022 Mar;226(3):379-383.
  9. Abdulhasan, M, Ruden, X, Rappolee, B, Dutta, S, Gurdziel, K, Ruden, DM, Awonuga A, Korzeniewski S, Puscheck K, and Rappolee, DA (2021). Stress decreases host viral resistance and increases Covid susceptibility in embryonic stem cells. Stem Cell Rev Rep 2021 Dec;17(6):2164-2177.
  10. Engmann L, Sun F, Legro RS, Diamond MP, Zhang H, Santoro N; Reproductive Medicine Network. Hum Reprod. Factors associated with study protocol adherence and bio banking participation in reproductive medicine clinical trials and their relationship to live birth. Reprod. 2020 Dec 1;35(12):2819-2831.
  11. Luis R. Hoyo, Sejal Tamakuwala, Anupama Rambhatla, Harpreet Brar, Gustavo Vilchez, Jenifer Allsworth, Javier Rodriguez-Kovacsc, Awoniyi Awonuga. Risk factors for cervical ectopic pregnancy. Journal of Gynecology Obstetrics and Human Reproduction. 2020;49:1-5.
  12. Mili Thakur, Anupama Rambhatla, Farnoosh Qadri, Charalampos Chatzicharalampous, Modupe Awonuga, Ghassan Saed, Michael P. Diamond, Awoniyi O. Awonuga. Is there a genetic predisposition to postoperative adhesion development? Reprod Sci. 2020 Oct 22:1-11.
  13. Van De Velde NA, Chatzicharalampous C, Awonuga AO. Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome. Case Rep Obstet Gynecol. 2020 Feb 8;2020:9210651. eCollection 2020.
  14. Roohi Jeelani, Charalampos Chatzicharalampous, Hamid-Reza Kohan-Ghadr, David Bai, Robert T. Morris, Inga Sliskovic, Awoniyi Awonuga and Husam M. Abu-Soud. Hypochlorous acid reversibly inhibits caspase-3: a potential regulator of apoptosis. Free Radical Research, 2020. Free Radic Res. 2020 Jan 7:1-14.
  15. Jahanbakhsh S, Dekhne MS, Kohan-Ghadr HR, Bai D, Awonuga A, Morris RT, Yang Z, Abu-Soud HM. The inhibition of lactoperoxidase catalytic activity through mesna (2-mercaptoethane sodium sulfonate). J Inorg Biochem. 2019 Nov 12;203:110911.
  16. Hoyos LR, Vilchez G, Allsworth JE, Malik M, Rodriguez-Kovacs J, Adekola H, Awonuga AO. Outcomes in subsequent pregnancies after wedge resection for interstitial ectopic pregnancy: a retrospective cohort study. J Matern Fetal Neonatal Med. 2019 Jul;32(14):2354-2360.
  17. AlrahmaniLβ, AbdelsattarZMβ, AdekolaHɣ, GonikB and AwonugaA. Adolescence and risk of preterm birth in multifetal gestations. J Matern Fetal Neonatal Med. 2019 Apr;32(8):1321-1324.

Awards
• American Society Reproductive Medicine Star Award: 2017, 2018, 2019, 2020, 2021, 2022
• National Council of Resident Education (CREOG) faculty awards for excellence in teaching: Maimonides Medical Center (2004), Medical College Georgia (2005), Wayne State University (2011)
• Women’s Reproductive Health Research Award (WHRH) Grant: 2010-2015.
• Wayne State University School of Medicine’s College Teaching Award 2013
• Kamran S. Moghissi, M.D. Faculty Award in excellence in teaching 2012.
• Who’s Who in America by Marquis Who’s Who: Annually since 2010
• America’s Top Obstetrician and Gynecologists by Consumers’ Research Council of America: Annually since 2006
• Excellence in Teaching Award, Department of Ob/Gyn Mount Sinai School of Medicine, NY. 2003

JOURNAL/EDITORIAL ACTIVITY:
Editorial Board Membership
Austin Journal of Obstetrics and Gynecology Journal of Gynecology
Journal of Gynecology and Pediatrics
Medical Journal of Obstetrics and Gynecology
Case Reports in Obstetrics and Gynecology
International Journal of fertility and sterility


Review of Manuscripts (All Ad Hoc): National
PLoS
Systems Biology in Reproductive Medicine
Journal of Pulmonary and Respiratory Medicine
Journal of Women's Health
Journal of Assisted Reproduction and Genetics.
Fertility & Sterility

Review of Manuscripts (All Ad Hoc): International
Drug Design, Development and Therapy
Asian Journal of Endoscopic Surgery
Archives of Medical Research
International Journal of Medicine
Obstetrics and Gynecology Investigation
Case Reports in Obstetrics and Gynaecology
Acta Obstetricia et Gynecologica Scandinavica
Journal of Obstetrics and Gynecology Research
Yonsei Medical Journal
European Journal of Obstetrics & Gynecology and Reproductive Biology
Human Reproduction, the Official Journal of The European Society of Human Reproduction and Embryology
International Journal of fertility and sterility

Current Grants on which I am the Principal Investigator:

  1.  A Randomized, Placebo-Controlled, Response-Guided, Intrasubject, Dose Escalation Study to Evaluate the Safety and Efficacy of Tildacerfont in Adult Subjects with Polycystic Ovary Syndrome (PCOS) and Elevated Adrenal Androgens. Sponsor: SPR001-210 – Spruce Biosciences, Inc.
  2. A Phase 3b Study to Evaluate the long-term Safety and Efficacy of Elagolix in Combination with Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated with Uterine Fibroids in Premenopausal Women. Source: AbbVie, Protocol Number M16-283
  3. A Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Combination with Estradiol/Norethindrone Acetate in Subjects with Moderate to Severe Endometriosis-Associated Pain (M14-702) Source: Abbvie 2016 – 2023, Grant number 25528
     

 

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