Professor and Director of Epigenomics - Institute of Environmental Health Sciences
Professor and Director of Epigenomics - Institute of Environmental Health Sciences (Joint)
BIOL 6330 - Lecturer. Department of Biology, Graduate Level Genetics.
Douglas Ruden is interested in how early exposures to environmental toxins such as lead affect genome-wide DNA methylation and histone modifications. He collaborates on projects on several model organisms, from the fruit fly Drosophilia melanogaster, the water flea Daphnia, honey bees and killer bees, to human neonatal dried blood spots and embryonic stem cells. Laboratory techniques include: DNA methylation analyses (BS-Seq and Infinium) and histone modification analyses (ChIP-Seq and mDIP-Seq). His laboratory collaborates with the Applied Technology Genomics Core (ATGC) which has both low throughput and high throughput technologies to accommodate investigators needs, e.g. Solexa next-generation sequencing and Illumina Bead Arrays.
- Elobeid, M.A., Padilla, M.A., Brock, D.W., Ruden, D.M., and Allison, D.B. (2010) Putative Endocrine Disrupting Chemicals and Obesity: An Examination of Dioxins in the NHANES 1999-2002 Data. Intern. J. Env. Res. Publ. Health 7(7), 2988-3005. PMID: 20717554
- Ruden, D.M. (2011). The (new) new synthesis and epigenetic capacitors of morphological evolution. Nat Genet 3(2), 88-89 PMID: 21270834Cingolani, P., Platts P., Wang, L.L., Coon, M., Nguyen, T.T., Wang, L., Land, S.J., Ruden, D. M., and Lu, X. (2012). A Program for
- Annotating and Predicting the Effects of Single Nucleotide Polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6(2), 80-92. PMID: 22728672Senut. M.C., Cingolani, P., Sen, A., Kruger, A., Shaik, A., Hirsch, H., Suhr, S.T., Ruden, D. (2012). Epigenetics of early-life lead exposure and effects on brain development. Epigenomics 4(6), 665-674. PMID: 23244311
- Figueroa-Romero, C., Hur, J., Bender, D.E., Cataldo, M.D., Lunn, S., Pacut, C., Smith, A.L., Delaney, C.E., Yung, R., Ruden, D.M., Callaghan, B.C., Feldman, E.L. (2012). DNA methylation and gene expression in sporadic amyotrophic lateral sclerosis. PLoS One, in press.