Douglas Ruden

Douglas Ruden

Professor and Director of Epigenomics - Institute of Environmental Health Sciences


Douglas Ruden

Academic Rank

 Professor and Director of Epigenomics - Institute of Environmental Health Sciences (Joint)

Courses taught

BIOL 6330 - Lecturer.  Department of Biology, Graduate Level Genetics.

CB 7990 - Lecturer.  Karmanos Cancer Institute, Research Technologies in Cancer Biology.
PHC 7650:  Epigenetics:  Dietary and Pharmacological Impacts on Health - Lecturer. Department of Pharmacology, Advance Topics in Pharmacology
PHC 7651:  Epigenetics Mini-Course and Laboratory - Course Master/Instructor. Department of Pharmacology.
MBG 8680:  Epigenetics Bioinformatics  - Instructor.  Center for Molecular Medicine and Genetics, Molecular Biology and Genomics.
PSL 7690:  Epigenetics during Early Development; Experimental Embryology 2; Experimental Embryology 3 - Instructor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Principles of Reproductive Biology.
PSL 7700:  Epigenetic Regulation of Stem Cells - Instructor.  Department of Physiology with Concentration in the Reproductive Sciences Program (PhD), Stem Cell Biology.
Advisor/Mentor.  Departments of Pharmacology and Biology, and Institute of Environmental Health Sciences PhD Programs:  Graduate Research; Laboratory Rotations; Doctoral Candidate Status: Thesis/Dissertation Research and Design; and Doctoral Candidate Dissertation Research and Direction:  Candidate Maintenance Status. 
Lecturer.  Department of Pharmacology Seminar Series:  Alternative Splicing in a Drosophila TBI Model. 
Lecturer.  Wayne State University Undergraduate Neuroscience Club (AXON):  Multigenerational Epigenetic Inheritance in Humans.


Douglas Ruden is interested in how early exposures to environmental toxins such as lead affect genome-wide DNA methylation and histone modifications. He collaborates on projects on several model organisms, from the fruit fly Drosophilia melanogaster, the water flea Daphnia, honey bees and killer bees, to human neonatal dried blood spots and embryonic stem cells. Laboratory techniques include: DNA methylation analyses (BS-Seq and Infinium) and histone modification analyses (ChIP-Seq and mDIP-Seq). His laboratory collaborates with the Applied Technology Genomics Core (ATGC) which has both low throughput and high throughput technologies to accommodate investigators needs, e.g. Solexa next-generation sequencing and Illumina Bead Arrays.


  • Elobeid, M.A., Padilla, M.A., Brock, D.W., Ruden, D.M., and Allison, D.B. (2010) Putative Endocrine Disrupting Chemicals and Obesity: An Examination of Dioxins in the NHANES 1999-2002 Data. Intern. J. Env. Res. Publ. Health 7(7), 2988-3005. PMID: 20717554
  • Ruden, D.M. (2011). The (new) new synthesis and epigenetic capacitors of morphological evolution. Nat Genet 3(2), 88-89 PMID: 21270834Cingolani, P., Platts P., Wang, L.L., Coon, M., Nguyen, T.T., Wang, L., Land, S.J., Ruden, D. M., and Lu, X. (2012). A Program for
  • Annotating and Predicting the Effects of Single Nucleotide Polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6(2), 80-92. PMID: 22728672Senut. M.C., Cingolani, P., Sen, A., Kruger, A., Shaik, A., Hirsch, H., Suhr, S.T., Ruden, D. (2012). Epigenetics of early-life lead exposure and effects on brain development. Epigenomics 4(6), 665-674. PMID: 23244311
  • Figueroa-Romero, C., Hur, J., Bender, D.E., Cataldo, M.D., Lunn, S., Pacut, C., Smith, A.L., Delaney, C.E., Yung, R., Ruden, D.M., Callaghan, B.C., Feldman, E.L. (2012). DNA methylation and gene expression in sporadic amyotrophic lateral sclerosis. PLoS One, in press.

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Other Information

 Institute of Environmental Health Sciences

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