Biography

Roslyn Tedja, PhD, is an Assistant Professor in the Department of Obstetrics and Gynecology. She received her Ph.D. degree in Chemical Engineering from the University of New South Wales, Sydney, Australia. Her laboratory focuses on identifying genetic changes that govern the initiation of epithelial-to-mesenchymal transition (EMT) in ovarian cancer progression, metastasis and recurrence. Additionally, her laboratory investigates the role of intra-tumoral heterogeneity in disease progression and recurrence. Her laboratory efforts also include designing novel nanoparticle platform for delivery of chemotherapy drugs to target residual disease.

Publications

• Robert CM, Cardenas C, Tedja R. The role of intra-tumoral heterogeneity and its clinical relevance in epithelial ovarian cancer recurrence and metastasis. 2019. Cancers. 11(8), 1083. (Impact factor: 6.2)
• Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. Protein kinase C⍺-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. 2019. J Biol Chem. 294(13), 5082-5093. (Impact factor: 4.3)
• Yang-Harwich Y, Tedja R, Roberts C, Goodner-Bingham J, Cardenas C, Gurea M, Sumi NJ, Alvero AB, Glackin CA, Mor G. p53-Pirh2 complex promotes Twist1 degradation and inhibits EMT in ovarian cancer cells. 2018. Mol Cancer Res. 17(1), 153-164. (Impact factor: 4.6)
• Tedja R, Soeriyadi AH, Whittaker MR, Lim M, Marquis C, Boyer C, Davis TP, Amal R. Effect of TiO2 nanoparticle surface functionalization on protein adsorption, cellular uptake and cytotoxicity: the attachment of PEG comb polymers using catalytic chain transfer and thiol-ene
• chemistry. 2012. Polymer Chemistry. 3, 2743-2751. (Impact factor: 5.4)
  Tedja R, Lim M, Amal R, Marquis C. Effects of serum adsorption on cellular uptake profile and consequent impact of titanium dioxide nanoparticles on human lung cell lines. 2012. ACS Nano. 6(5), 4083-4093. (Impact factor: 13.9)
• Tedja R, Marquis C, Lim M, Amal R. Biological impacts of TiO2 on human lung cell line A549 and H1299: particle size distribution effects. 2011. J Nanopart Res. 13(9), 3801-3813. (Impact factor: 2.1)
  
  Selected publications

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